论文部分内容阅读
肿瘤抗原MAGE A3为肿瘤共同抗原 ,广泛表达于多种组织类型的肿瘤细胞 ,而在正常组织细胞 (除睾丸和胎盘外 )却不表达。该抗原不仅能被HLAⅠ类分子呈递 ,而且能被HLAⅡ类分子呈递。MAGE A3抗原已被广泛应用于肿瘤治疗性疫苗的研究。
The tumor antigen MAGE A3 is a tumor common antigen that is widely expressed in many tissue types of tumor cells but not in normal tissue cells (except testis and placenta). The antigen can not only be presented by HLA class I molecules but also be presented by HLA class II molecules. MAGE A3 antigen has been widely used in the research of tumor therapeutic vaccines.