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目的:观察二甲双胍对非胰岛素依赖型糖尿病(NIDDM)的疗效。方法:28例NIDDM病人(男性17例,女性11例,年龄58±s10a),在用足量的磺酰脲类降糖药无效时加用二甲双胍,开始剂量为250~500mg/d,根据血糖调整剂量,最大剂量为1.5g/d。治疗3mo。结果:空腹和餐后2h血糖、糖基化血红蛋白和24h尿糖均明显降低(P<0.01)。空腹血糖和餐后2h血糖控制总有效率为89%。有腹泻和恶心各3例。结论:二甲双胍治疗NIDDM病人效果满意。
Objective: To observe the effect of metformin on non-insulin-dependent diabetes mellitus (NIDDM). METHODS: Twenty-eight NIDDM patients (17 males and 11 females, age 58 ± s10a) were treated with metformin when sufficient sulfonylurea hypoglycemic agents were ineffective with a starting dose of 250-500 mg / Adjust the dose, the maximum dose of 1.5g / d. Treatment 3mo. Results: Both fasting and 2h postprandial blood glucose, glycosylated hemoglobin and 24 h urine glucose were significantly decreased (P <0.01). Fasting blood glucose and postprandial blood glucose control 2h total efficiency of 89%. There are 3 cases of diarrhea and nausea. Conclusion: Metformin treatment of NIDDM patients with satisfactory results.