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目的探讨患者输血前不规则抗体筛查在安全输血中的意义,为更好的指导临床用血。方法采用微柱凝胶法对1825例需要输血的患者进行输血前不规则抗体筛查。结果 1825例输血治疗患者中检出不规则抗体12例,阳性率0.66%;其中女9例,均有妊娠史,男3例,男女均有输血史。对于申请输血的12例阳性患者经过提前选择无相应抗原的红细胞均无溶血性输血反应发生。结论妊娠和反复输血可使患者不规则抗体阳性率增高,所以输血前检测不规则抗体能更好的防止溶血性输血反应的发生,提高输血的安全性。
Objective To investigate the significance of irregular antibody screening before transfusion in patients with transfusion and to guide the clinical use of blood. Methods The microcolumn gel method was used to screen 1825 patients who needed blood transfusion before irregular blood transfusion. Results Among the 1825 transfusion patients, 12 cases were found to have irregular antibodies, the positive rate was 0.66%. Among them, 9 cases were women with pregnancy history and 3 males, both of whom had transfusion history. 12 cases of positive patients applying for blood transfusion after no pre-selection of the corresponding antigen-resistant erythrocytes were hemolytic transfusion reactions. Conclusion Pregnancy and repeated blood transfusion can increase the positive rate of irregular antibody in patients. Therefore, the detection of irregular antibodies before transfusion can better prevent the occurrence of hemolytic transfusion reaction and improve the safety of blood transfusion.