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天然免疫限制因子Tetherin(骨髓基质细胞抗原2)是Ⅰ型干扰素诱导产生的Ⅱ型跨膜蛋白.Tetherin通过其特殊的拓扑结构,在病毒出芽过程中将病毒粒子连接在细胞膜表面,限制病毒的有效释放,从而发挥广谱性的抗病毒活性,而病毒也可以通过多种策略拮抗Tetherin的抗病毒活性.病毒与宿主长期抗争进化的结果表现为病毒特定拮抗蛋白对抗不同种属细胞Tetherin的限制存在种属特异性.本文通过对Tetherin的分子结构、抗病毒活性及其拮抗蛋白的对抗机制等最新进展进行综述,为研究病毒与宿主相互作用的分子机制以及新型抗病毒药物的筛选提供借鉴.
Tetherin is a type II transmembrane protein induced by type I interferons.Tether through its specific topological structure, in the virus sprouting process will be connected to the virus particles on the cell membrane surface, limiting the virus Effective release, and thus play a broad spectrum of antiviral activity, and the virus can also be antagonized by a variety of strategies Tetherin antiviral activity.Viral long-term evolution of the host and the result of the evolution of virus-specific antagonist protein against different species of Tetherin cells limit There are species-specific.In this paper, we review the molecular structure of Tetherin, the antiviral activity and antagonistic mechanism of Tetherin, and so on, so as to provide reference for studying the molecular mechanism of virus-host interaction and screening new antiviral drugs.