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目的了解济宁市某院骨科住院患者2014年第二、四季度抗菌药物使用情况及临床分离菌对常用抗菌药物的耐药情况,为骨科临床合理用药提供参考。方法收集济宁市某医院药房2014年第二、四季度骨科抗菌药物使用量和用药频度(DDDs)以及来自检验科分离的有关骨科住院患者感染的致病菌种类和构成比,利用药敏实验对代表性致病菌进行耐药性分析。结果 2014年第四季度骨科住院患者抗菌药物使用率为22.79%,较第二季度(32.81%)有所下降,第四季度抗菌药物使用频度[(DDDs)]为209.81,较第二季度(256.73)有所下降。2014年第二、第四季度分别分离出56株、43株致病细菌,革兰阳性菌有金黄色葡萄球菌、表皮葡萄球菌、溶血葡萄球菌和奇异变形菌等,革兰阴性菌有铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌和鲍曼不动杆菌等。表皮葡萄球菌对各类抗菌药物的耐药性与铜绿假单胞菌对各类抗菌药物的耐药性之间的差异较大。结论某院骨科住院患者的抗菌药物使用情况得到了明显的控制。
Objective To investigate the use of antibacterials in the second and fourth quarters of 2014 in patients with orthopedic inpatient of a hospital in Jining City and the resistance of clinical isolates to commonly used antibacterials, so as to provide a reference for the clinical use of orthopedics. Methods The dosage and frequency of orthodontic antibiotics (DDDs) in the pharmacy of a hospital in Jining City in 2014 were collected, and the types and composition of pathogenic bacteria in hospitalized patients with orthopedic diseases were collected. Resistance analysis of representative pathogenic bacteria. Results In the fourth quarter of 2014, the usage rate of antimicrobials in orthopedic inpatients was 22.79%, down from the second quarter (32.81%). In the fourth quarter, the frequency of antimicrobial use [DDDs] was 209.81, 256.73) declined. In the second and fourth quarters of 2014, 56 strains and 43 pathogenic bacteria were isolated respectively. Gram-positive bacteria were Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus aureus and Staphylococcus aureus. Aeromonas, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii and so on. Staphylococcus epidermidis resistant to various antimicrobial agents and Pseudomonas aeruginosa large differences between the various antimicrobial resistance. Conclusion The use of antimicrobial agents in hospital orthopedic patients has been obviously controlled.