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目的探讨联合检测血清AFP、GGT-II和GGT在诊断原发性肝癌中的价值,以提高原发性肝癌的早期诊断率。方法选择PLC 36例、肝硬化63例、病毒性肝炎78例、肝损伤14例、肝良性肿瘤8例和正常对照者46例,血清AFP,GGT-Ⅱ及GGT分别采用化学发光免疫分析法、自然不连续缓冲系统聚丙烯酰胺凝胶垂直电泳检测法和全自动生化仪进行检测。结果 PLC组AFP为3285±932μg/L,GGT为297±201U/L,显著高于肝硬化组(AFP:414±285μg/L,P<0.01;GGT:222±149U/L,P<0.05)、病毒性肝炎组(AFP:114±114μg/L,P<0.01;GGT:181±134 U/L,P<0.05),肝损伤组(AFP:20±20μg/L,P<0.01),肝良性肿瘤组(AFP:4.4±2.9μg/L,P<0.01;GGT:201±111U/L,P<0.05)及正常对照者组(AFP:3.2±1.1μg/L,P<0.01;GGT:31±6.1U/L,P<0.05);诊断肝癌的特异性AFP最高(90%),灵敏度最高为GGT-Ⅱ(92%);将三者联合检测,则诊断原发性肝癌的灵敏度可达到95%。结论肿瘤标志物的联合检测可提高原发性肝癌的确诊率,具有较好的临床应用价值。
Objective To explore the value of combined detection of serum AFP, GGT-II and GGT in the diagnosis of primary liver cancer so as to improve the early diagnosis rate of primary liver cancer. Methods 36 cases of PLC, 63 cases of liver cirrhosis, 78 cases of viral hepatitis, 14 cases of liver injury, 8 cases of benign liver tumor and 46 cases of normal control were selected. Methods Serum AFP, GGT-Ⅱ and GGT were detected by chemiluminescence immunoassay, Natural discontinuous buffer system polyacrylamide gel electrophoresis test and automatic biochemical analyzer. Results The AFP of PLC group was 3285 ± 932μg / L and GGT was 297 ± 201U / L, which was significantly higher than that of cirrhosis group (AFP: 414 ± 285μg / L, P <0.01; GGT: 222 ± 149U / L, (AFP: 114 ± 114μg / L, P <0.01; GGT: 181 ± 134 U / L, P <0.05) and liver injury group (AFP: 20 ± 20μg / L, (AFP: 4.4 ± 2.9μg / L, P <0.01; GGT: 201 ± 111U / L, P <0.05) and normal control group 31 ± 6.1U / L, P <0.05). The highest specificity of AFP in diagnosis of hepatocellular carcinoma was 90% and the highest sensitivity was GGT-Ⅱ (92%). Reached 95%. Conclusion The combined detection of tumor markers can improve the diagnosis of primary liver cancer, and has a good clinical value.