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本文采用荧光偏振免疫分析法(简称FPIA)测定55例胃疾病患者的胃液、血清、胃窦粘膜中庆大霉素的浓度,结果表明,口服庆大霉素后经较长时间在胃液和胃窦粘膜组织中,可保持较高的有效浓度,其中18例口服庆大霉素4万U 后12h 胃液浓度为50.33±12.64μg/ml;4例24h 胃液庆大霉素浓度为46±6.6μg/ml;25例患者口服庆大霉素4万U 后12h 胃窦粘膜浓度为3.17±1.24ug/g,而血清中庆大霉素未检出。这项工作为临床合理使用庆大霉素提供了科学依据。
In this paper, fluorescence polarization immunoassay (FPIA) was used to determine the concentration of gentamicin in the gastric juice, serum and antral mucosa of 55 patients with gastric diseases. The results showed that after gentamicin oral administration for a long time, In sinus mucosa tissue, higher effective concentration could be maintained. The gastric juice concentration was 50.33 ± 12.64μg / ml at 12h in 18 cases of gentamicin 40 000 U. The concentration of gentamicin in 24h gastric juice was 46 ± 6.6μg / ml; 25 patients after oral gentamicin 40 000 U 12h gastric mucosa was 3.17 ± 1.24ug / g, while the serum gentamicin was not detected. This work provides a scientific basis for clinical use of gentamicin.