论文部分内容阅读
目的 进一步探讨脂蛋白(α)[LP(α)]在成人原发性肾病综合征(PNS)发生发展中的作用。方法 应用单克隆抗体浊度法检测76例PNS患者血清LP(α)水平,分析不同病理类型PNS患者血清LP(α)是否存在差异;并对LP(α)水平与PNS患者病情严重程度以及与其它血脂项目的关系作相关分析。结果 PNS患者血清LP(α)水平显著高于正常对照组(P<0.005);各病理类型血清LP(α)水平差异无统计学意义(P>0.05);PNS患者血清LP(α)水平与24h尿蛋白排泄量(24h-UPE)呈正相关,与血清白蛋白(ALB)水平呈负相关关系;PNS患者血清LP(α)水平与血清甘油三酯(TG)及极低密度脂蛋白(VLDL)水平呈高度正相关关系,而与胆固醇(CH)及低密度脂蛋白(LDL)相关性无统计学意义,也与高密度脂蛋白(HDL)相关关系无统计意义。结论 血中LP(α)异常升高可能参与PNS的发病过程;LP(α)代谢异常与PNS的原发病因无关,PNS发生后所继发的机体代谢异常可能是引起血清LP(α)水平升高的主要原因;积极诱导PNS缓解或者尽可能的降低尿蛋白不仅对控制肾脏内损伤具有巨大意义,而且对减少肾外并发症的发生具有重要意义。
Objective To investigate the role of lipoprotein (α) [LP (α)] in the development of adult primary nephrotic syndrome (PNS). Methods Serum LP (α) levels were measured by monoclonal antibody turbidimetry in 76 PNS patients. The LP (α) levels of PNS patients with different pathological types were analyzed. The relationship between LP (α) level and the severity of PNS Other lipids related to the project for the relevant analysis. Results The serum level of LP (α) in patients with PNS was significantly higher than that in the normal controls (P <0.005). There was no significant difference in serum LP (α) levels between various pathological types (P> 0.05) (24 h-UPE), but negatively correlated with serum albumin (ALB). Serum LP (α) levels were positively correlated with serum triglyceride (TG) and VLDL ), While there was no significant relationship with cholesterol (CH) and low density lipoprotein (LDL), but also with high density lipoprotein (HDL). Conclusions The abnormal LP (α) in blood may be involved in the pathogenesis of PNS. The abnormal metabolism of LP (α) has nothing to do with the primary etiopathogenisis of PNS. The abnormal metabolism may be the cause of serum LP (α) The main reason for the increased; positive induction of PNS or minimize urinary protein not only for the control of renal damage has great significance, but also to reduce the incidence of extra-renal complications of great significance.