【摘 要】
：
Gasdermins (GSDMs) belong to a protein superfamily that is found only in vertebrates and consists of GSDMA,GSDMB,GSDMC,GSDMD,DFNA5 (a.k.a.GSDME) and DFNB59 (a.k
【机 构】
：
The Joint Center for Infection and Immunity between Guangzhou Institute of Pediatrics, Guangzhou Wom
论文部分内容阅读
Gasdermins (GSDMs) belong to a protein superfamily that is found only in vertebrates and consists of GSDMA,GSDMB,GSDMC,GSDMD,DFNA5 (a.k.a.GSDME) and DFNB59 (a.k.a.Pejvakin (PJVK)) in humans.Except for DFNB59,all members of the GSDM superfamily contain a conserved twodomain structure (N-terminal and C-terminal domains) and share an autoinhibitory mechanism.When the N-terminal domain of these GSDMs is released,it possesses pore-forming activity that causes inflammatory death associated with the loss of cell membrane integrity and release of inflammatory mediators.It has also been found that spontaneous mutations occurring in the genes of GSDMs have been associated with the development of certain autoimmune disorders,as well as cancers.Here,we review the current knowledge of the expression profile and regulation of GSDMs and the important roles of this protein family in inflammatory cell death,tumorigenesis and other related diseases.
其他文献
Spliceosomal RNAs are a family of small nuclear RNAs (snRNAs) that are essential for pre-mRNA splicing.All vertebrate spliceosomal snRNAs are extensively pseudo
Glycogen synthase kinase-3 (GSK-3) is a highly conserved and multifunctional serine/threonine protein kinase widely distributed in eukaryotic cells.GSK-3 is ori
The aspartate kinase (AK) from Mycobacterium tuberculosis (Mtb) catalyzes the biosynthesis of aspartate family amino acids,including lysine,threonine,isoleucine
土壤次生盐渍化是温室蔬菜生长的主要障碍之一,严重制约设施蔬菜的可持续高效发展。黄瓜作为我国设施主栽蔬菜之一,属于盐敏感植物,土壤次生盐渍化危害尤为严重。磷脂酶D(PLD
Atherosclerosis is a progressive vascular disease with increasing morbidity and mortality year by year in mode society.Human cytomegalovirus (HCMV) infection is
Dementia,a devastating neurological disorder commonly found in the elderly,is characterized by severe cognitive and memory impairment.Ample clinical and epidemi
试验于2011-2013年在山东农业大学园艺科学与工程学院进行，以平邑甜茶幼苗为试材，盆栽条件下，探讨了不同有机物料的发酵流体（厌氧发酵产物）与堆肥（有氧发酵产物）对苹果连作土壤环境
As a major type of immune cells with heterogeneity and plasticity,macrophages are classically divided into inflammatory (M1) and alternative/anti-inflammatory (
The human CCR4-NOT deadenylase complex consists of at least nine enzymatic and non-enzymatic subunits.Accumulating evidence suggests that the non-enzymatic subu
Atherosclerosis is the pathological basis of most cardiovascular diseases,the leading cause of morbidity and mortality worldwide.Kallistatin,originally discover