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自 2 0世纪 60年代初 ,医学界对慢性心力衰竭 (ＣＨＦ)时神经内分泌改变进行了大量研究。 90年代初 (1 992年 )Ｐａｃｋｅｒ提出解释心力衰竭进展的神经内分泌假说 ,愈来愈多的证据表明 ,心力衰竭是神经内分泌系统介导的慢性全身性适应反应。有关其病理生理的现代观点认为主要
Since the early 1960s, a large number of studies have been conducted in the medical community on neuroendocrine changes in patients with chronic heart failure (CHF). In the early 1990s (1992) Packer proposed a neuroendocrine hypothesis that explained the progression of heart failure. There is increasing evidence that heart failure is a neuro-endocrine system-mediated chronic systemic adaptive response. The modern view of its pathophysiology is of primary importance