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目的 探讨胃癌患者手术前后红细胞免疫功能、T细胞亚群的变化及其相关性 ,为其免疫防治提供理论依据。方法 应用免疫粘附法和SAP法对 3 5例胃癌患者手术前后的红细胞免疫活性 (RBC -C3bRR、RBC -ICR和RBC -TRR )和外周血T细胞亚群 (CD3 + 、CD4+ 、CD8+ 和CD4+ /CD8+ )进行检测。结果 手术前红细胞C3bRR、TRR和CD3 + 、CD4+ 及CD4+ /CD8+ 显著低于手术后和正常对照组 ( 3 2例 ) (P <0 .0 1)。而RBC -ICR和CD8+ 在手术前显著高于手术后和对照组 (P <0 .0 1)。胃癌患者手术前后的红细胞C3bRR和TRR与CD4+ /CD8+ 均呈正相关 (P<0 .0 5 )。结论 手术可以明显改善胃癌患者红细胞与淋巴细胞的免疫功能。动态联合检测上述指标有助于了解病情严重程度 ,监测手术效果及开展围手术期免疫保护。
Objective To investigate the changes of erythrocyte immune function and T cell subsets in patients with gastric cancer before and after operation, and to provide a theoretical basis for their immune control. Methods The immune activity of erythrocytes (RBC-C3bRR, RBC-ICR and RBC-TRR) and peripheral T cell subsets (CD3 +, CD4 +, CD8 + and CD4 + / CD8 +) for testing. Results Before surgery, the levels of C3bRR, TRR, CD3 +, CD4 + and CD4 + / CD8 + in erythrocytes were significantly lower than those in postoperative and normal controls (32 cases) (P <0.01). However, RBC-ICR and CD8 + were significantly higher in preoperative and postoperative patients than in controls and controls (P <0.01). The levels of C3bRR, TRR and CD4 + / CD8 + in patients with gastric cancer before and after surgery were positively correlated (P <0.05). Conclusion Surgery can significantly improve the immune function of erythrocytes and lymphocytes in patients with gastric cancer. Dynamic joint detection of the above indicators help to understand the severity of the disease, monitor the effect of surgery and carry out perioperative immune protection.