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目的评价不同种类、不同剂量的基因重组乙型肝炎(乙肝)疫苗对新生儿免疫后6年的免疫效果。方法连续对2003-2004年出生、母亲乙肝病毒表面抗原(HBsAg)阴性、接受过0月、1月、6个月程序基因重组乙肝疫苗免疫的218名新生儿进行追踪观察6 a,采用血清流行病学方法,对接种重组乙肝疫苗【中国仓鼠卵细胞(CHO细胞)】和不同剂量的重组乙肝疫苗(酵母)的3组儿童进行免疫效果比较。结果重组乙肝疫苗(CHO细胞)的乙肝表面抗体(抗-HBs)阳转率总体趋势优于重组乙肝疫苗(酵母)。结论两种不同种类的基因重组乙肝疫苗对新生儿免疫后效果良好,母亲HBsAg阴性新生儿完成基因重组乙肝疫苗全程接种后,在6 a的随访期间,不同疫苗组间抗体阳转率和抗体浓度下降趋势一致。
Objective To evaluate the immune effects of different types and doses of recombinant hepatitis B (HBV) vaccine on newborns six years after immunization. Methods 218 newborn babies born from 2003 to 2004 who were negative for maternal hepatitis B virus surface antigen (HBsAg), and who received recombinant hepatitis B vaccine during the months of January, January and 6 months were followed up for 6 years. The immunological efficacy of three groups of children vaccinated with recombinant hepatitis B vaccine [Chinese hamster ovary (CHO) cells] and different doses of recombinant hepatitis B vaccine (yeast) were compared. Results The overall trend of hepatitis B surface antigen (anti-HBs) positive rate of recombinant hepatitis B vaccine (CHO cells) was better than that of recombinant hepatitis B vaccine (yeast). Conclusions After immunization with two different kinds of recombinant hepatitis B vaccines, the results showed that the HBsAg negative newborns completed the whole course of genetic recombinant hepatitis B vaccination. During the 6-year follow-up period, the antibody positive rate and antibody concentration Down trend consistent.