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冠状动脉急性阻塞几小时内,40%—50%的病人死于心室颤动。急性期死亡率主要取决于梗塞区的大小。有巨大梗塞区的病人,左心功能很差,易于产生心原性休克,梗塞晚期常出现室性心律失常和继发性心室纤颤。梗塞区大小的重要性,随着时间的推移逐渐下降。几个月后晚期死亡率与梗塞区大小关系不大。药物缩小梗塞区,可减少早期死亡率。一、冠状动脉闭塞后心肌梗塞区在几小时或几天内完全形成。二、冠状动脉结扎后,采取药物治疗,可缩小实验性心肌梗塞的范围。
Within a few hours of acute coronary occlusion, 40% to 50% of patients die of ventricular fibrillation. Acute phase mortality mainly depends on the size of the infarct zone. Patients with a large infarct area, poor left ventricular function, prone to produce cardiogenic shock, ventricular arrhythmia and secondary ventricular fibrillation often appear late infarction. The importance of infarct size declines over time. A few months later mortality and infarct size has little to do. Drugs reduce the infarct area, can reduce the early mortality. First, myocardial infarction after coronary artery occlusion in a few hours or days completely formed. Second, coronary artery ligation, to take medication, can reduce the scope of experimental myocardial infarction.