肺癌直接侵袭胸膜或转移致胸膜产生癌性胸腔积液，严重影响生存质量，亦是造成肺癌患者气急、胸闷、胸痛，甚至死亡原因之一。1994年1月至1998年5月，我们应用凝血酶、丝裂霉素联合治疗晚期肺癌胸腔积液患者20例，收到良好效果，现报告如下：1临床资料癌性胸腔积液患者20例，男 Lung cancer directly invades the pleura or causes pleural effusion resulting in metastatic pleural effusion, which severely affects the quality of life. It is also one of the causes of lung cancer patients with shortness of breath, chest tightness, chest pain, and even death. From January 1994 to May 1998, we used thrombin and mitomycin for the treatment of 20 patients with advanced lung cancer with pleural effusion. The results are as follows: 1 Clinical data 20 patients with cancerous pleural effusion ,male