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目的探讨帕金森病(Parkinson’s disease,PD)患者合并不宁腿综合征(restless leg syndrome,RLS)的临床特点,且进一步研究PD患者合并RLS的相关因素。方法选取确诊的119例PD患者,根据是否合并RLS分为伴RLS组和单纯PD组,分别比较2组的一般状况、病史、临床表现、严重程度、合并症、治疗情况等临床资料。结果 119例PD患者中26例合并RLS,发生率为20.8%,且RLS均出现在PD症状后。2组在UPDRS、HAMD、HAMA、PSQI上有统计学差异(P<0.05),而在一般状况、主要症状、左旋多巴治疗等方面均未见统计学差异(P>0.05)。另外,发现左旋多巴的日剂量与RLS严重度之间存在正相关关系,即服用左旋多巴剂量越大,RLS程度越重。结论 RLS可能是PD病程中出现的一种并发症。PD运动症状较严重、并发症较多时合并RLS的可能性相对较大,随着多巴胺能药物剂量的加大,RLS的病情可能加重。
Objective To investigate the clinical features of restless leg syndrome (RLS) in patients with Parkinson’s disease (PD) and further study the related factors of RLS in patients with PD. Methods A total of 119 patients with PD were enrolled in this study. The clinical data including general condition, medical history, clinical manifestation, severity, comorbidities and treatment were compared between the two groups according to whether they were divided into RLS group and PD group. Results Of the 119 patients with PD, 26 had RLS with a incidence of 20.8%, and all the RLS occurred after PD. There were significant differences in UPDRS, HAMD, HAMA and PSQI between the two groups (P <0.05), but there were no significant differences in the general status, major symptoms and levodopa therapy (P> 0.05). In addition, there was a positive correlation between the daily dose of levodopa and the severity of RLS, ie the greater the dose of levodopa, the more severe the RLS. Conclusions RLS may be a complication in the course of PD. PD more serious symptoms of movement, complications associated with the possibility of RLS is relatively large, with the dose of dopaminergic increased, RLS may aggravate.