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一般认为对细胞内病原体的抵抗力取决于淋巴细胞和巨噬细胞的相互作用,如这两类细胞之一有缺陷将增加宿主对细胞内病原体的易感性。瘤型麻风患者的淋巴细胞功能失常,表现为对皮试抗原的反应减退,异体植皮的存活期延长,淋巴细胞对分裂原的反应减弱等,但这类异常反应经过有效治疗后多数可以恢复,只有对麻风杆菌抗原的不反应性才是瘤型患者唯一特有的免疫异常。曾有报导瘤型患者不能消化死(加热灭活)的麻风杆菌,并认为某些人所以患瘤型麻风是由于其巨噬细胞对麻风杆菌的
It is generally accepted that the resistance to intracellular pathogens depends on the interaction of lymphocytes and macrophages, and that if one of these two types of cells is defective, they increase the susceptibility of the host to intracellular pathogens. Tumor patients with leprosy lymphocyte dysfunction, manifested as skin test antigen response diminished allogeneic skin graft survival, lymphocyte response to mitogen decreased, but such an abnormal response after the majority of effective treatment can be restored, Only the non-response to the leprosy antigen is the only unique immunologic abnormality in the neoplastic patient. There have been reports of leprosy that can not be digested dead (heat inactivated) in a patient with a neoplasia, and it is believed that some people suffer from leprosy because of their macrophages’