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ANP可治疗缺血性水肿,但对出血性水肿作用鲜为人知。 本文观察组在左皮质下尾状核(Caudatep-utamem)注入细菌胶元酶0∶4u,4小时后ANP120或100μg/kg腹膜腔注入,每20小时一次。对照组脑注入盐水并持续腹膜腔输注ANP300或700μg/kg24小时。24小时取出脑冷却至-70℃,每半球切成4份,检测每份含水量、血浆钾钠及渗透克分子浓度。另12只家免病损后4或7小时腹膜腔注入甘露醇。最后一组脑内注入2μl含0.08μg,1.6μg或8.0μg 8—溴—环磷酸鸟苷。
ANP can treat ischemic edema, but the role of hemorrhagic edema is little known. The observation group was injected with bacterial cellozyme 0: 4u in Caudatep-utamem, and injected with ANP120 or 100μg / kg peritoneal cavity 4 hours later, once every 20 hours. The control group was injected with saline and intraperitoneal infusion of ANP300 or 700 μg / kg for 24 hours. After 24 hours, the brains were removed and cooled to -70 ° C. Each hemisphere was cut into 4 portions. Each portion of water was tested for plasma potassium sodium and osmolarity. The other 12 patients were injected into the peritoneal cavity with mannitol 4 or 7 hours after injury-free. The last group was injected intraperitoneally with 2 μl of 8-bromo-cyclic guanosine monophosphate containing 0.08 μg, 1.6 μg or 8.0 μg.