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近年来的临床试验与基础研究表明 ,3羟 - 3甲基 -戊二酰辅酶 A (HMG- Co A)还原酶抑制剂 (他汀类药 )除肯定的降低血浆胆固醇 (主要作用 )外 ,可能尚涉及不依赖于胆固醇降低的非调脂抗动肮粥样硬化机制如改善内皮功能、抑制血管平滑肌细胞增殖与迁移、抗炎症反应、促进斑块稳定、抑制血小板聚集等。探讨他汀类药调脂以外的抗动脉粥样硬化作用有助于全面了解该类药在预防、治疗冠状动脉疾病中所居的地位。
In recent years, clinical trials and basic research have shown that 3 HMG-CoA reductase inhibitors (statins), in addition to certain plasma cholesterol lowering (the main effect), may Still involved in not dependent on cholesterol-lowering non-lipid-lowering anti-inflammatory atherosclerosis mechanisms such as improving endothelial function, inhibition of vascular smooth muscle cell proliferation and migration, anti-inflammatory response, promote plaque stability, inhibition of platelet aggregation. To investigate the anti-atherosclerosis effect of statins other than lipid-lowering helps to fully understand the position of these drugs in the prevention and treatment of coronary artery disease.