系统性红斑狼疮(SLE)的淋巴细胞异常,表现为B细胞功能亢进和T细胞缺陷。但引起这些异常的原因以及哪种异常发生在先都尚未明确。本文就SLE动物模型及SLE患者的淋巴细胞异常,怎样参与发病过程加以说明。作为SLE模型动物,有NZB、(NZB×NZW)F_1,MRL/L、BXSB、SWan、M-otheaten等小鼠以及与人类SLE更近似的狗模型,这些都为SLE的研究作出了贡献。各种同系交配小鼠的临床表现和血清学所见,虽然与SLE很相似,但不同系鼠间所表现出 Lymphoid cells in systemic lupus erythematosus (SLE) are abnormally characterized by hyperthyroidism and T cell defects. However, the causes of these abnormalities and what kind of anomalies occur first are not yet clear. In this paper, SLE animal model and SLE patients with lymphocyte abnormalities, how to participate in the pathogenesis to be described. As SLE model animals, there are NZB, (NZB × NZW) F_1, MRL / L, BXSB, SWan, M-otheaten and other mice and dog models that are more similar to human SLE, all contributing to the research of SLE. The clinical manifestations and serological findings of various syngenic mating mice, although similar to SLE, are shown in different mouse lines