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以戊唑醇(TBA)为模型药物,可生物降解的乙酸纤维素(CA)为载体材料,利用高压静电技术,制备了载药微球和载药纳米纤维缓释剂,并对载药微球和载药纳米纤维的释放过程进行了研究,同时采用扫描电子显微镜、红外光谱仪对载药微球和载药纳米纤维的结构和形貌进行了表征。结果表明,在缓释剂制备过程中,CA溶液浓度对载药缓释剂的形貌有较大的影响,CA溶液质量分数为4%时,制得的缓释剂为球形结构;CA溶液质量分数为15%时,制得的缓释剂为纳米纤维结构。载药微球和载药纳米纤维均具有一定的缓释性能,对白色念珠菌具有明显的抗菌效果。
Taking tebuconazole (TBA) as model drug and biodegradable cellulose acetate (CA) as carrier material, drug-loaded microspheres and drug-loaded nanofibers were prepared by high voltage electrostatic technique. The release process of the drug-loaded nanofibers and the drug-loaded nanofibers was studied. The structure and morphology of drug loaded microspheres and drug loaded nanofibers were characterized by scanning electron microscopy and infrared spectroscopy. The results showed that the concentration of CA solution had a significant effect on the morphology of drug-loaded sustained-release agent in the process of preparation of sustained-release agent. When CA content was 4%, the sustained- When the mass fraction is 15%, the prepared sustained-release agent is a nanofiber structure. Drug-loaded microspheres and drug-loaded nanofibers have a certain degree of sustained-release properties, Candida albicans has obvious antibacterial effect.