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目的 分析长期存活肾移植患者环孢素 A( Cs A)血浓度监测的临床意义。 方法 采用荧光偏振免疫法 ( FPIA)测定 674例肾移植患者5 3 93例次 Cs A血药浓度 ,根据术后时间分为正常组、中毒组、排异组 ,分析其疗效 ;并对其术后时间、年龄、药物相互作用、存活情况等进行统计分析。 结果 中毒组、排异组与正常组相比 ,Cs A全血药浓度有显著性差异 ( P<0 .0 1) ;在同一时间段内 Cs A血药浓度随着年龄的增长呈下降趋势 ,术后时间 1年以上 ,3组患者的 Cs A血药浓度范围重叠较大。 结论 根据 Cs A血药浓度监测结果及时调整给药方案 ,实行个体化给药方案 ,合理用药 ,建立长期随访制度 ,及时发现和处理并发症 ,是提高长期存活率的根本保证之一
Objective To analyze the clinical significance of monitoring CsA concentration in long-term survival renal transplant recipients. Methods The plasma concentration of 5 3 93 CsA in 674 renal transplant recipients was measured by fluorescence polarization immunoassay (FPIA). The plasma concentration of CsA was divided into normal group, poisoning group and rejection group according to the postoperative time, and its effect was analyzed. After time, age, drug interactions, survival and other statistical analysis. Results The concentrations of CsA in whole blood of poisoning group and rejection group were significantly different from those of normal group (P <0.01). The concentration of CsA in plasma decreased with age at the same time , And the postoperative time was over 1 year. The concentration of CsA in three groups overlapped greatly. Conclusion According to the monitoring result of CsA blood concentration, it is one of the fundamental guarantees to improve the long-term survival rate that timely adjust the dosage regimen, implement the individualized dosage regimen, administer the drug rationally, establish the long-term follow-up system, and find and manage the complications in time