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目的探讨血清超敏C反应蛋白(HsCRP)及视黄醇结合蛋白(RBP)检测在糖尿病患者早期肾损伤中的诊断意义。方法根据尿微量白蛋白(mALB)的量将82例2型糖尿病患者分为无肾病组(<25mg/L)37例、肾病组(25-200mg/L)45例,另选40例健康体检者作为正常对照组,对所有受检者均进行HsCRP及RBP的检测并进行比较。结果糖尿病肾病组血清HsCRP及RBP均明显高于正常对照组(P<0.01),差异有统计学意义。结论血清HsCRP及RBP检测是糖尿病患者早期肾损害诊断的敏感指标。
Objective To investigate the diagnostic value of serum hsCRP and retinol binding protein (RBP) in the diagnosis of early renal injury in diabetic patients. Methods According to the amount of urine microalbumin (mALB), 82 patients with type 2 diabetes were divided into 37 patients without nephropathy (<25mg / L), 45 patients with nephropathy (25-200mg / L) and 40 patients As a normal control group, all subjects were tested for HsCRP and RBP and compared. Results Serum HsCRP and RBP in diabetic nephropathy group were significantly higher than those in normal control group (P <0.01), the difference was statistically significant. Conclusion Serum HsCRP and RBP detection is a sensitive indicator of early renal damage in diabetic patients.