狼疮性肾炎(LN)是影响系统性红斑狼疮(SLE)预后的重要脏器合并症之一。SLE的全过程中50%～60%合并LN,但其发病与遗传因素相关。以往,WHO分类Ⅳ型狼疮性肾炎(弥漫增生型)的5年生存率不及20%,是极为恶性的疾病。但最近,5年生存已近80%。这不仅与治疗方法的改进有关,而且与诊断法 Lupus nephritis (LN) is one of the major organ complications affecting the prognosis of systemic lupus erythematosus (SLE). The whole process of SLE 50% to 60% of LN, but its incidence and genetic factors. In the past, the WHO classification of type IV lupus nephritis (diffuse proliferative) 5-year survival rate of less than 20%, is a very malignant disease. But recently, 5-year survival has nearly 80%. This is not only related to the improvement of the treatment method, but also to the diagnosis