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AIM:To investigate the chemical constituents of the roots of Polygala sibirica L.(Polygalaceae) METHOD:The isolation was performed by solvent extraction and various chromatographic techniques,including silica gel,Sephadex LH-20,ODS,semi-preparative HPLC,and preparative TLC.The chemical structures were elucidated based on extensive spectroscopic analysis,including HR-ESI-MS and 1D- and 2D-NMR spectroscopic data.RESULTS:A total of sixteen compounds,including five xanthones(5,7–10),five saccharide esters(1,3,4,12,13),two flavonoids(14,16),two triterpenoids(11,15),one phenylpropanoid(6),and one benzophenone glycoside(2) were isolated.Their structures were determined as sibiricose A7(1),sibiriphenone A(2),polygalatenoside A(3),polygalatenoside C(4),lancerin(5),3,4,5-trimethoxycinnamic acid(6),6-hydroxy-1,2,3,7-tetramethoxyxanthone(7),1,3,7-trihydroxy-2-methoxyxanthone(8),onjixanthone II(9),1,2,3,6,7-pentamethoxyxanthone(10),presenegenin(11),3’-O-3,4,5-trimethoxycinnamoyl-6-O-4-methoxy benzoyl sucrose(12),tenuifoliside C(13),5,3’-dihydroxy-7,4’-dimethoxyflavonol-3-O-β-D-glucopyranoside(14),tenuifolin(15),and rhamnetin 3-O-β-D-glucopyranoside(16).CONCLUSION:Compounds 1 and 2 are two new compounds from P.sibirica.
AIM: To investigate the chemical constituents of the roots of Polygala sibirica L. (Polygalaceae) METHOD: The isolation was performed by solvent extraction and various chromatographic techniques, including silica gel, Sephadex LH-20, ODS, semi-preparative HPLC, and preparative TLC. The chemical structures were elucidated based on extensive spectroscopic analysis, including HR-ESI-MS and 1D- and 2D-NMR spectroscopic data .RESULTS: A total of sixteen compounds, including five xanthones (5,7-10), five saccharide esters (1,3,4,12,13), two flavonoids (14,16), two triterpenoids (11,15), one phenylpropanoid (6), and one benzophenone glycoside sibiricose A7 (1), sibiriphenone A (2), polygalatenoside A (3), polygalatenoside C (4), lancerin (5), 3,4,5-trimethoxycinnamic acid , 7-tetramethoxyxanthone (7), 1,3,7-trihydroxy-2-methoxyxanthone (8), onjixanthone II (9), 1,2,3,6,7-pentamethoxyxanthone (10), presenegenin ’-O-3,4,5-trimethoxycinnamoyl-6-O-4-methoxy ben zuyl sucrose (12), tenuifoliside C (13), 5,3’-dihydroxy-7,4’-dimethoxyflavonol-3-O- β -D- glucopyranoside (14), tenuifolin (15), and rhamnetin 3-O- β-D-glucopyranoside (16). CONCLUSION: Compounds 1 and 2 are two new compounds from P.sibirica.