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以体外培养的小鼠肝细胞为模型,采用四甲基偶氮唑盐(MTT)比色法,观察了不同剂量丹参素对肝细胞增殖的影响及其对D-半乳糖胺(GalN)致肝细胞损伤的保护作用。结果表明:丹参素能直接刺激肝细胞增殖,而且二者之间具有一定的剂量依赖关系;丹参素对GalN引起的肝细胞损伤和坏死也具有保护作用。
The effect of different doses of Danshensu on the proliferation of hepatocytes and its effect on D-galactosamine (GalN) were studied using MTT colorimetric method. The protective effect of hepatocyte injury. The results showed that: Danshensu can directly stimulate hepatocyte proliferation, and there is a dose-dependent relationship between them; Danshensu also has a protective effect on GalN-induced hepatocyte injury and necrosis.