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利用单克隆抗体及生物素－亲和素放大系统检测青霉素抗原特异性ＩｇＥ，并探讨其临床意义。结果５９例青霉素Ⅰ型变态反应患者中青霉素特异性ＩｇＥ总阳性率为８８．１１％（５２／５９）；１４例门诊皮试假阳性患者特异性ＩｇＥ阴性，使用青霉素无不良反应；９例猩红热样皮疹青霉素过敏患者中１例特异性ＩｇＥ阳性；而３１５例非青霉素过敏者，其ＢＰＯ特异性ＩｇＥ均阴性，且其中部分患者使用青霉素亦无过敏反应。本文方法有特异性强、敏感性较高的特点。
The use of monoclonal antibodies and biotin-avidin amplification system detection of penicillin antigen-specific IgE, and explore its clinical significance. Results The total positive rate of penicillin-specific IgE in 59 patients with penicillin-type Ⅰ allergy was 88.11% (52/59). Fourteen outpatients with false-positive skin test negative for specific IgE had no adverse reactions with penicillin. Nine cases of scarlet fever One case of specific IgE was positive in the sample-like rash penicillin allergy, while 315 cases of non-penicillin allergy were all BPO-specific IgE negative, and some of them also did not have any allergic reaction to penicillin. This method has the characteristics of strong specificity and high sensitivity.