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特异性较强的多巴胺受体激动剂,例如:bromocriptine, lergotrile, pergolide和N,N-di-n-propyl-dopamine等,可降低神志清醒的自发性高血压大鼠和某些麻醉动物的血压。这种降压作用由于可被某些多巴胺受体阻断剂所对抗,因而被认为是刺激多巴胺受体所致。在理论上多巴胺激动剂的主要两种降压机制为:(1)外周多巴胺Ⅰ型受体激活而直接使平滑肌松弛;(2)外周神趣节和交感神程末稍多巴胺Ⅱ型受体激活使去甲肾上腺素释放减少。其他次要机制还可包括尿钠排出增多或醛固酮分泌减少等。由
Specific dopamine receptor agonists such as bromocriptine, lergotrile, pergolide and N, N-di-n-propyl-dopamine, can reduce the blood pressure in conscious spontaneous hypertensive rats and some anesthetic animals . This hypotensive effect is believed to be due to stimulated dopamine receptors due to its antagonism by certain dopamine receptor blockers. In theory, the main two antihypertensive mechanisms of dopamine agonists are: (1) Peripheral dopamine type I receptor activation directly relaxes smooth muscle; (2) Peripheral neurons and sympathetic terminal dopamine type II receptor activation Reduces norepinephrine release. Other secondary mechanisms may also include increased urinary sodium excretion or decreased aldosterone secretion. by