Objective:The aim of our study was to analyze hepatic dysfunction and failure after hepatocellular carcinoma (HCC) resection and relationship of clinical and pathological factors.Methods:Clinical and pathological data of 467 HCC patients was retrospectively reviewed,who underwent liver resection from January 2002 to December 2008 in the Affiliated Hospital of Medical College,Qingdao University,and the post-resectional liver dysfunction and failure risk factors were analyzed by univariate and multivariate analysis.Results:The morbidity of post-resectional liver dysfunction and failure was 1.7% and 2.1%.The post-resectional liver dysfunction and failure after HCC hepatectomy into the statistical analysis:univariate analysis revealed preoperative platelet level (<100×109/L),serum albumin level (<35 g/L),serum gamma-Glutamyl transferase (> 64 U/L),Child-Pugh classification (B),MELD score (≥9),intraoperative bleeding (≥1000 mL),blood transfusion were positive factors,multivariate analysis (Logistic) revealed that preoperative platelet level (0.983,95% CI=0.971-0.995) and intraoperative blood transfusion (3.145,95% CI=1.027-12.028) were independent risk factors for post-resectional liver dysfunction and failure.Conclusion:Prevented liver failure and liver dysfunction occurring after liver resection,it is the key to accurate preoperative assessment of liver function and the patient’s reserved liver functional,precise hepatectomy and reasonable blockage of hepatic inflow. Objective: The aim of our study was to analyze hepatic dysfunction and failure after hepatocellular carcinoma (HCC) resection and relationship of clinical and pathological factors. Methods: Clinical and pathological data of 467 HCC patients was retrospectively reviewed, who underwent liver resection from January 2002 to December 2008 in the Affiliated Hospital of Medical College, Qingdao University, and the post-resectional liver dysfunction and failure risk factors were analyzed by univariate and multivariate analysis. Results: The morbidity of post-resectional liver dysfunction and failure was 1.7% and 2.1 %. The post-resectional liver dysfunction and failure after HCC hepatectomy into the statistical analysis: univariate analysis revealed preoperative platelet level (<100x109 / L), serum albumin level (<35 g / L), serum gamma- Glutamyl transferase > 64 U / L), Child-Pugh classification (B), MELD score (≥9), intraoperative bleeding (≥1000 mL), blood transfusion were positive factors, multivariate analy were independent risk factors for post-resectional liver dysfunction and failure. Conlusion: sis (Logistic) revealed that preoperative platelet level (0.983, 95% CI = 0.971-0.995) and intraoperative blood transfusion (3.145, 95% CI = 1.027-12.028) Prevented liver failure and liver dysfunction occurring liver resection, it is the key to accurate preoperative assessment of liver function and the patient’s reserved liver functional, precise hepatectomy and reasonable blockage of hepatic inflow.