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目的评估处于临床缓解期B系淋巴瘤患者的细胞免疫状态。方法应用流式细胞分析技术检测我院2010年11月至2014年7月处于临床缓解期的34例B系淋巴瘤患者外周血T细胞亚群。结果缓解期B系淋巴瘤患者外周血CD3~+、CD3~+CD4~+T淋巴细胞亚群及CD4~+/CD8~+均低于健康对照组(P<0.05);惰性B系淋巴瘤患者外周血CD3~+、CD3~+CD4~+、CD3~+CD56~+T淋巴细胞亚群及CD4~+/CD8~+均较侵袭性B系淋巴瘤患者高(P<0.05)。结论缓解期B系淋巴瘤患者仍存在细胞免疫功能低下,且侵袭性较惰性淋巴瘤免疫功能紊乱更严重。
Objective To assess the cellular immune status of patients with B lymphoma in clinical remission. Methods Flow cytometry was used to detect T lymphocyte subsets in peripheral blood of 34 patients with B lymphoma who were in clinical remission from November 2010 to July 2014 in our hospital. Results CD3 ~ +, CD3 ~ + CD4 ~ + T lymphocyte subsets and CD4 ~ + / CD8 ~ + in peripheral blood of patients with B lymphoma were significantly lower than those in healthy controls (P <0.05) The levels of CD3 ~ +, CD3 ~ + CD4 ~ +, CD3 ~ + CD56 ~ + T lymphocytes and CD4 ~ + / CD8 ~ + in peripheral blood of patients with invasive B lymphoma were significantly higher than those of patients with aggressive B lymphoma (P <0.05). Conclusions Patients with B lymphoma in remission still have low cellular immune function and more severe immune dysfunction in aggressive lymphoma.