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目的通过氪激光光凝青紫兰兔,建立动物视网膜激光损伤模型。方法应用氪激光对14只青紫兰兔实验眼视网膜进行光凝,波长647nm、功率380～400mw、光斑直径50μm、曝光时间0.05s,创建动物模型。光凝后3、7、14、21、28、56d和84d行眼底荧光血管造影(fundus fluorescein angiography,FFA)和眼底照像后处死动物,进行组织病理学检查。结果组织病理学检查发现,光凝后呈现动态的非特异性的损伤修复过程。结论通过氪激光光凝青紫兰兔,建立动物视网膜激光损伤模型是可行、有效的,可用来进行光凝损伤病变的防治研究。
Objective To establish an animal model of retinal laser injury by krypton laser photocoagulation of Cymbidium blue rabbits. Methods Krypton laser was applied to photocoagulate the retina of 14 rabbits in experimental group. The wavelength was 647nm, the power was 380-400mw, the spot diameter was 50μm, and the exposure time was 0.05s. Animal model was established. Histopathological examination was performed after fundus fluorescein angiography (FFA) and fundus photography at 3,7,14,21,28,56 and 84 days after photocoagulation. Results Histopathological examination revealed a dynamic non-specific injury repair process after photocoagulation. Conclusion It is feasible and effective to establish animal model of retinal laser injury by krypton laser photocoagulation of Cymbidium blue rabbits, which can be used to study the prevention and treatment of photodamage.