论文部分内容阅读
目的:评价大分割伽玛射线立体定向放射治疗对颅内转移瘤的临床疗效。方法:采用陀螺旋转式伽玛射线立体定向放射设备治疗颅内转移瘤患者91例。单纯伽玛射线立体定向放射治疗采取大分割分次方式,处方剂量3.2-5Gy,每周5次,计划靶区边缘(45%或65%等剂量线处)总剂量全程为35-50Gy。结果:近期有效率(CR+PR)颅内移瘤少于3个组为93.06%(67/72),大于3个组为73.69%(14/19);局部剂量与肿瘤复发的关系,照射剂量50GY者复发率为11.86%(7/59),照射剂量为40GY者复发率为31.25%(10/32);生存率陀螺刀治疗的中位生存期为11.9个月。6、12、24个月生存率分别为:76.92%(70/91)、60.44%(55/91)、29.67%(27/91)。结论:大分割伽玛射线立体定向放射治疗脑部和体部恶性肿瘤近期疗效满意。
OBJECTIVE: To evaluate the clinical effect of large fractionated gamma-ray stereotactic radiotherapy on intracranial metastases. Methods: Totally 91 patients with intracranial metastases were treated with gyro-rotating gamma-ray stereotactic radiosurgery. Simple gamma-ray stereotactic radiotherapy to take large fractionation method, the prescription dose of 3.2-5Gy, 5 times a week, the planned target edge (45% or 65% isodose line) total dose of 35-50Gy. Results: There were 93.06% (67/72) cases of less than 3 cases of CR + PR, 73.69% (14/19) cases of more than 3 cases. The relationship between local dose and tumor recurrence, The relapse rate was 11.86% (7/59) in 50GY and 31.25% (10/32) in 40GY. The median survival of gyro knife with survival rate was 11.9 months. The survival rates at 6, 12 and 24 months were 76.92% (70/91), 60.44% (55/91) and 29.67% (27/91), respectively. Conclusion: The large-fractionated gamma-ray stereotactic radiotherapy is satisfactory for the short-term curative effect of brain and body malignant tumors.