尿中草酸、草酸钙晶体是影响尿石形成的主要因素,但一般只是把它们作为结石的一种成分来看待。近年发现草酸(Ox)、草酸钙晶体(COM)对肾脏上皮细胞有毒性作用,它们和上皮细胞作用产生毒性物质造成上皮的损伤,同时上皮细胞也主动摄入晶体、分泌大分子物质,二者相互作用最终导致结石的形成。这些发现也许能为结石形成机制的研究提供一个新的思路。 Urine oxalic acid, calcium oxalate crystals are the main factors that affect the formation of uroliths, but generally only treat them as a component of stones. In recent years, oxalic acid (Ox) and calcium oxalate crystals (COM) have been found to have a toxic effect on renal epithelial cells. They interact with epithelial cells to produce toxic substances that cause epithelial damage. Epithelial cells also actively take up crystals and secrete macromolecules, both The interaction eventually leads to the formation of stones. These findings may provide a new insight into the mechanism of stone formation.