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目的 较为系统地了解药物蛋白的聚乙二醇修饰过程。方法 根据现有文献 ,就聚乙二醇类修饰剂选择、修饰反应原理与操作条件、过程设计与产品纯化、生物化学和生物学分析定性等问题作出简要论述。结果与结论 聚乙二醇修饰后的蛋白质被赋予了许多新的物理化学和生物学特性 ,以及临床效果得到了明显改善 ,显示了药物蛋白的聚乙二醇修饰的良好应用前景。
Objective To understand the polyethylene glycol modification process of pharmaceutical protein more systematically. Methods According to the existing literatures, the problems of polyethylene glycol modifier selection, modification reaction principle and operating conditions, process design and product purification, biochemistry and biological analysis qualitative were briefly discussed. RESULTS AND CONCLUSION Polyethylene glycol modified protein was endowed with many new physicochemical and biological properties, and the clinical effect was significantly improved, indicating the good application prospect of the polyethylene glycol modified by the drug protein.