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本文报道两种不同给药途径的薄荷油对小白鼠终止妊娠作用的初步观察结果:于孕d_6,将4μl薄荷油或橄榄油分别注入右侧宫角,左侧宫角不给药,于孕d_(11)剖检。给薄荷油侧与橄榄油侧宫角妊娠终止率分别为100%与41. 67％,差别显著。于孕d_4～10,各组分别肌注薄荷油一次,于孕d_(11)剖检。薄荷油不同剂量皆有一定抗着床与抗早孕作用,作用强度随剂量增加,0. 035ml/只,抗着床率达100％。终止妊娠的原因可能是子宫收缩加强,也不能排除蜕膜组织等的直接损伤。
This article reported two different routes of administration of peppermint oil on the termination of pregnancy in mice on the initial observation of the results: in pregnancy d_6, 4μl peppermint oil or olive oil were injected into the right uterine horn, left uterine horn do not give, in pregnancy D_(11) necropsy. The rate of termination of pregnancy for peppermint oil and olive oil was 100% and 41.67%, respectively. In pregnancy d_4 ~ 10, each group were intramuscular injection of peppermint oil once, in pregnancy d_ (11) necropsy. Different doses of peppermint oil have a certain anti-implantation and anti-pregnancy effects, the role of intensity increases with the dose, 0. 035ml / only, anti-implantation rate of 100%. Termination of pregnancy may be due to increased uterine contractions, and it does not exclude direct damage to the decidua.