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目的探讨苁蓉精联合卡左双多巴控释片治疗早期帕金森病(PD)病人的临床疗效。方法 PD病人根据意愿,选择采用西药治疗或西药加苁蓉精治疗,分为对照组和治疗组。对照组给予卡左双多巴控释片初始剂量250 mg,每日两次口服治疗;治疗组在对照组基础上加用苁蓉精(肉苁蓉、淫羊藿、黄精组成)治疗,疗程均为3个月。观察治疗前后进行统一帕金森病评定量表(UPDRS)评分、中医证候量化评分表评分。结果治疗组治疗后UPDRS总分为15.68分±6.32分,对照组治疗后UPDRS总分为16.12分±4.55分,两组比较差异无统计学意义(P>0.05);治疗组治疗后中医证候量化评分与治疗前相比显著降低(P<0.05),中医证候量化评分总有效率治疗组为71.4%,对照组为60.0%,差异有统计学意义(P<0.05)。结论苁蓉精联合卡左双多巴控释片治疗早期PD病人可明显改善中医证候评分。
Objective To investigate the clinical curative effect of Cistanche combined with carbophyll-double-controlled release on patients with early Parkinson’s disease (PD). Methods According to the wishes of patients with PD, choose Western medicine or Western medicine plus Cistanche treatment, divided into control group and treatment group. The control group was given carbodihydroprusside controlled-release tablets initial dose of 250 mg, twice daily oral treatment; the treatment group on the basis of the control group plus Cistanche (Cistanche, Epimedium, Polygonatum composition) treatment, treatment were 3 months. Observed before and after treatment were unified Parkinson’s Disease Rating Scale (UPDRS) score, TCM Syndrome Quantified score scale. Results The total score of UPDRS in the treatment group after treatment was 15.68 ± 6.32 points, while the UPDRS score in the control group was 16.12 ± 4.55 after treatment. There was no significant difference between the two groups (P> 0.05) The quantification score was significantly lower than that before treatment (P <0.05). The total effective rate of TCM syndrome quantification score was 71.4% in the treatment group and 60.0% in the control group, the difference was statistically significant (P <0.05). Conclusion Cistanche combined card with levodopa release tablets in patients with early treatment of PD can significantly improve the TCM syndrome score.