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目的探讨双歧三联活菌胶囊对结肠造口术后腹泻患者肠道菌群及肠黏膜屏障功能的影响。方法选取外科门诊就诊结肠造口术后腹泻患者82例,随机分为观察组和对照组各41例。两组患者均予以口服补液盐、止泻药等常规治疗。观察组加用双歧三联活菌胶囊温水口服,630mg/次,2次/d,连用4周。于治疗前后观察两组患者肠道菌群数量及肠黏膜屏障功能指标的变化,并比较其临床效果。结果治疗4周后,两组患者双歧杆菌、乳杆菌数量及B/E比值上升,大肠埃希菌和肠球菌数量下降(P<0.05),且观察组变化幅度更大;两组患者血清D-乳酸和二胺氧化酶(DAO)水平降低(P<0.05或P<0.01),且观察组下降幅度更大(P<0.05);在总有效率上观察组较对照组更佳(P<0.05)。结论双歧三联活菌胶囊治疗结肠造口术后腹泻患者效果较佳,机制与其能调节肠道微生态平衡紊乱,重建肠道微生态平衡,并能保护与修复肠黏膜屏障,减少其通透性,改善肠道功能密切相关。
Objective To investigate the effects of bifid triple-viable capsule on intestinal microflora and intestinal mucosal barrier function in patients with post-colostomy diarrhea. Methods Eighty-two patients with postoperative colostomy diarrhea were selected and randomly divided into observation group and control group with 41 cases each. Two groups of patients were given oral rehydration salts, antidiarrheal drugs and other conventional treatment. Observation group plus bifid triple viable capsule warm water oral, 630mg / time, 2 times / d, once every 4 weeks. The changes of intestinal microflora and functional indexes of intestinal mucosal barrier in both groups were observed before and after treatment, and their clinical effects were compared. Results After 4 weeks of treatment, the number of Bifidobacterium and Lactobacillus and the ratio of B / E increased, the number of Escherichia coli and Enterococcus decreased (P <0.05), and the changes in the observation group were more obvious. The serum levels of Bifidobacterium D-lactate and diamine oxidase (DAO) levels decreased (P <0.05 or P <0.01), and the observation group decreased more significantly (P <0.05); the total effective rate in the observation group was better than the control group <0.05). Conclusion Bifid triple viable capsule in patients with postoperative colostomy diarrhea better effect, mechanism and its ability to regulate intestinal microflora balance disorders, reconstruction of intestinal microflora balance, and to protect and repair the intestinal mucosal barrier and reduce its permeability Sexual, improve intestinal function is closely related.