采用放免法测定２４例食管贲门癌患者围手术期血清皮质醇水平，并取３０例正常人做对照。结果：食管贲门癌患者血清皮质醇水平显著低于正常人（Ｐ＜０．０５），术前低于术后即刻和术后１天（Ｐ值分别＜０．０５和０．００１），术后３天又恢复到术前水平。上述血清皮质醇的动态变化具有重要临床意义。 The perioperative serum cortisol levels in 24 patients with esophageal and cardiac cancer were measured by radioimmunoassay and 30 normal subjects were used as controls. Results: Serum cortisol levels in patients with esophageal and cardiac cancer were significantly lower than those in normal subjects (P<0.05). Preoperative values ​​were lower than those immediately after surgery and 1 day after surgery (P values ​​<0.05 and 0.001, respectively). After 3 days, she returned to preoperative level. The above-mentioned dynamic changes in serum cortisol have important clinical significance.