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研究氯喹非松（ＣＰＰ）疗法的抗炎机理及疗效。方法：８２例哮喘患儿随机分为ＣＰＰ组和对照组，观察 ＣＰＰ组治疗前后 ＰＥＦ和 ＰＩＥＯ－ＰＥＦ的变化，并行两组疗效比较。 ６０只豚鼠被分为 ６组，致敏后给药并收集支气管肺泡灌洗液（ＢＡＬ），行ＷＢＣ和Ｅｏｓ计数。结果：（１）ＣＰＰ组经ＣＰＰ治疗后，哮喘的临床控制率为７３．０８％（３８／５２）、显效２１．１５％（１１／５２）、好转５．７８％（３／５２）、无效为０。对照组分别为３、１１、１４和２例，临床控制率两组差异有显著性（Ｐ＜０．０１）。ＣＰＰ组治疗后ＰＥＦ与ＰＤ－ＰＥＦ明显升高，ＢＨＲ下降（ｔ＝６２．０８，ｔ＝１７３．９４，均Ｐ＜０．０１）。（２）ＢＡＬ．液中ＷＢＣ和Ｅｏｓ计数均提示，氯喹可代替半量泼尼松。结论：该疗法对小儿哮喘疗效满意，哮喘动物模型证实其抗炎症效应明显。
To study the anti-inflammatory mechanism and efficacy of chloroquine non-pine (CPP) therapy. Methods: Eighty-two asthmatic children were randomly divided into CPP group and control group. The changes of PEF and PIEO-PEF before and after CPP were observed, and the curative effect was compared between the two groups. Sixty guinea pigs were divided into six groups. After sensitization, bronchoalveolar lavage fluid (BAL) was collected and collected for counting WBC and Eos. Results: (1) After CPP treatment, the clinical control rate of asthma was 73.08% (38/52), 21.15% (11/52), 5.78% (3/52) Invalid The control group were 3, 11, 14 and 2 cases respectively. The clinical control rate had significant difference between the two groups (P <0.01). PEF and PD-PEF were significantly increased and BHR decreased after CPP treatment (t = 62.08, t = 173.94, all P <0.01). (2) BAL. Liquid WBC and Eos count suggest that chloroquine can replace half the amount of prednisone. Conclusion: The therapy is effective in treating pediatric asthma. The animal model of asthma confirmed its anti-inflammatory effect.