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目的 探讨nm2 3 H1蛋白表达与胃癌转移的关系。方法 应用ABC免疫组织化学方法 ,检测197例胃癌患者nm2 3 H1蛋白表达。分析nm2 3 H1表达与经典的胃癌临床病理参数以及生存期进行比较。结果 nm2 3 H1在胃癌组织染色阳性率为 45 .18% (89/ 197)。nm2 3 H1表达在肠型胃癌中高于弥漫型胃癌 ,其阳性率分别为 83.82 % (5 7/ 6 8)和 2 4.81% (32 / 12 9) ,P <0 .0 1。nm2 3 H1表达与有无淋巴结转移有关 ,有或无淋巴结转移者nm2 3 H1阳性率分别为 39.6 8% (5 0 / 12 6 )和 5 4.93% (39/ 71) ,P <0 .0 1。有远处转移者表达阳性率为2 7.5 0 % (11/ 40 ) ,无远处转移者阳性率为 49.6 8% (78/ 15 7) ,P <0 .0 5。nm2 3 H1表达与肿瘤浸润深度也有关 ,T1、T2、T3、T4的阳性率分别为 75 .0 0 % (2 1/ 2 8)、77.5 5 % (38/ 49)、2 6 .0 9% (2 4/ 92 )和 2 1.43% (6 / 2 8) ,P <0 .0 5。nm2 3 H1表达与肿瘤分化程度无明显相关 ,在分化好 ,分化中等和分化差的胃癌中表达阳性率分别为 5 4.5 4% (2 4/ 44 )、45 .0 7% (32 / 71)和 40 .2 4% (33/ 82 )。生存≥ 5年者nm2 3 H1表达阳性率为 5 9.6 8% (74/ 12 4) ,<5年者为 2 0 .5 5 % (15 / 73) ,P <0 .0 1。结论 nm2 3 H1表达与胃癌有无淋巴结远处转移和生存期有关 ,是反映
Objective To investigate the relationship between nm23-H1 protein expression and gastric cancer metastasis. Methods ABC immunohistochemistry was used to detect the expression of nm23 H1 in 197 cases of gastric cancer. Analysis of nm23 H1 expression and clinical pathological parameters of classic gastric cancer and survival were compared. Results The positive staining rate of nm23 H1 in gastric carcinoma was 45.18% (89/197). The positive rate of nm23 H1 expression in intestinal type gastric cancer was higher than that in diffuse type gastric cancer, the positive rate was 83.82% (57/68) and 2. 4.81% (32/129) respectively, P <0.01. The positive rates of nm23 H1 in patients with and without lymph node metastasis were 39.6 8% (5 0/126) and 5 4.93% (39/71), respectively, P <0.01 . The positive rate of distant metastasis was 2 7.5 0% (11/40), and the positive rate of distant metastasis was 49.6 8% (78/157), P <0. 05. The expression of nm23 H1 was also related to the depth of tumor invasion. The positive rates of T1, T2, T3 and T4 were 75.0% (2 1/2), 77.5 5% (38/49), 26.09 % (2 4/92) and 2 1.43% (6/2 8), P <0. 05. The positive expression rate of nm23 H1 was not significantly correlated with the degree of tumor differentiation. The positive expression rates of nm23 H1 were 54.5% (24/44), 45.0% (32/71) in poorly differentiated, moderately differentiated and poorly differentiated gastric cancer, respectively And 40.24% (33/82). The positive rate of nm23 H1 in patients who survived for 5 years was 59.68% (74/124), those in 5 years were 25.5% (15/73), P <0.01. Conclusion The expression of nm23 H1 is correlated with the distant metastasis and survival of gastric cancer