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目的研究血清鳞状细胞癌抗原(SCC-Ag)水平的变化对口腔鳞癌患者预后的影响。方法采用ELISA检测了58例口腔鳞状细胞癌(鳞癌)患者手术前后血清SCC-Ag水平的改变。结果术前及术后血清SCC-Ag值<1.5μg/L的口腔鳞癌患者术后发生复发或转移发生率为15.6%和3.1%;术前和术后血清SCC-Ag水平>1.5μg/L的口腔鳞癌患者术后发生复发或转移发生率为83.3%和95.5%;术前血清SCC-Ag水平>1.5μg/L的口腔鳞癌患者术后血清SCC-Ag水平下降且SCC-Ag值<1.5μg/L,其术后复发或转移发生率为25%。结论血清SCC-Ag可能与口腔鳞癌的发生发展有关,其结果可作为判断患者病情的进展及肿瘤是否复发或转移。
Objective To investigate the effect of serum SCC-Ag level on the prognosis of patients with oral squamous cell carcinoma. Methods The changes of serum SCC-Ag levels in 58 cases of oral squamous cell carcinoma (SCC) before and after operation were detected by ELISA. Results The incidence of recurrence or metastasis was 15.6% and 3.1% in patients with oral squamous cell carcinoma with SCC-Ag value <1.5μg / L preoperatively and postoperatively respectively. The preoperative and postoperative serum SCC-Ag levels were 1.5μg / L in patients with oral squamous cell carcinoma, the incidence of recurrence or metastasis was 83.3% and 95.5% respectively. Serum SCC-Ag levels were decreased in patients with oral squamous cell carcinoma with preoperative serum SCC-Ag level> 1.5μg / L and SCC-Ag Value <1.5μg / L, the incidence of recurrence or metastasis after surgery was 25%. Conclusions Serum SCC-Ag may be related to the occurrence and development of oral squamous cell carcinoma. The results may be used to judge the progression of the patient’s condition and whether the tumor recurred or metastasized.