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目的 探讨急性脑梗死患者血浆内皮素、血管紧张素、一氧化氮的动态变化及其临床意义。方法 测定2 0例健康对照组及 40例急性脑梗死患者急性期不同时段的血浆内皮素 (ET1)、血管紧张素Ⅱ (ATⅡ)、一氧化氮 (NO)的含量。结果 与健康组比较 ,急性脑梗死患者发病 2 4小时内ET1、ATⅡ 、NO均开始明显升高 ,第 3～ 4天仍维持于高水平 ,一周后开始下降 ,NO一周后下降至正常水平 ,ET1、ATⅡ二周后下降至正常水平。结论 急性脑梗死患者其血浆ET1、ATⅡ 、NO均发生动态变化 ,并在发病过程中发挥重要的作用。
Objective To investigate the dynamic changes of plasma endothelin, angiotensin and nitric oxide in patients with acute cerebral infarction and its clinical significance. Methods The levels of endothelin (ET1), angiotensin Ⅱ (AT Ⅱ) and nitric oxide (NO) in 20 healthy subjects and 40 patients with acute cerebral infarction at different periods of acute phase were measured. Results Compared with the healthy group, the levels of ET1, ATⅡ and NO in the patients with acute cerebral infarction began to increase obviously within 3-4 hours of onset, remained high in the third to fourth days, decreased in the first week, decreased to the normal level in the first week, ET1, ATⅡ decreased to normal level after two weeks. Conclusion The plasma levels of ET1, ATⅡ, NO in patients with acute cerebral infarction have dynamic changes and play an important role in the pathogenesis.