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下咽癌预后很差,不管采用何种疗法,五年生存率只有15～20%(Batsakis,1979)。作者自1978～1981年间采用顺氯氨铂、长春新碱和争光霉素,对22例Ⅲ、Ⅳ期下咽癌病人术前作了两个疗程的化疗,取得较好效果。方法是经一夜水合疗法后,第一天用2小时以上时间给顺氯氨铂80 mg/m~2;第三天静注长春新碱1 mg/m~2;6小时后,连续用5天争光霉素15u/m~2/日。第22天开始重复一个疗程。在第30～35天之间做下咽癌手术。结果:20/22例经2个疗程化疗后,肉眼观癌肿消退者1例,缩小一半以上者19例,缩小不到一半者1例,病情反有进展者1例。4例发现
Hypopharyngeal cancer has a poor prognosis, and regardless of the type of therapy used, the five-year survival rate is only 15-20% (Batsakis, 1979). The authors used cisplatin, vincristine, and bleomycin from 1978 to 1981, and performed two courses of chemotherapy for 22 patients with stage III and IV hypopharyngeal cancer before surgery, and achieved good results. The method was to take cisplatin 80 mg/m~2 for more than 2 hours on the first day after the hydration therapy overnight; on the third day, intravenous vincristine 1 mg/m~2; 6 hours later, continuous use 5 Congratulations on day 15μ/m~2/day. On the 22nd day, repeat a course of treatment. Hypopharyngeal cancer surgery was performed between days 30 and 35. RESULTS: After 20/22 patients received chemotherapy for 2 cycles, one case of macroscopic cancer regressed, 19 cases reduced by more than half, 1 case decreased by less than half, and 1 case progressed. 4 cases found