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目的：探讨 ２型糖尿病（ＤＭ）患者血栓素 Ａ２（ＴＸＡ２）和前列环素（ＰＧＩ２）失衡及 ＰＬＡ活性变化。方法：以放免法测定血栓素Ｂ２和６－酮－前列腺素含量，以改良Ｚｉｅｖｅ法测定血浆ＰＬＡ２活性，同时观察空腹血糖（ＦＢＧ）、空腹胰岛素（ＦＩＮＳ）、甘油三酯（ＴＧ）等的变化。结果：①２型ＤＭ患者存在ＴＸＡ２和ＰＧＩ２合成异常，且Ⅱ组（有微血管病变组）较Ⅰ组（无微血管病变组）更为严重；②２型 ＤＭ患者组血浆 ＰＬＡ２显著低于正常对照组，但 Ⅰ组与Ⅱ组之间无显著差异；③２型 ＤＭ患者组 ＴＸＢ２与ＦＢＧ、ＴＧ显著正相关，６－Ｋ—ＰＧＦ１８ＦＩＮＳ显著负相关，ＴＸＢ２与６－Ｋ－ＰＧＦ１ａ均与血浆ＰＬＡ２无显著相关性。结论：①ＴＸＡ２和 ＰＧＩ２失衡在 ２型糖尿病及其微血管病变的发生发展中起重要作用；③血浆分泌型 ＰＬＡ２活性变化与 ２型糖尿病密切有关，但在糖尿病患者ＴＸＡ２和ＰＧＩ２失衡及微血管病变中可能不起直接作用；③糖脂代谢紊乱以及高胰岛素血症在ＴＸＡ和ＰＧＩ２失衡及ＤＭ微血管病变中起重要作用。
Objective: To investigate the imbalance of thromboxane A2 (TXA2) and prostacyclin (PGI2) and the changes of PLA activity in type 2 diabetic patients. Methods: The levels of B2 and 6-keto-prostaglandin were determined by radioimmunoassay. The plasma PLA2 activity was measured by modified Zieve method. The changes of fasting blood glucose (FBG), fasting insulin (FINS), triglyceride . Results: ①There were TXA2 and PGI2 abnormalities in type 2 DM patients, and group Ⅱ (with microvascular disease group) was more serious than group Ⅰ (no microangiopathy group). ② Plasma PLA2 in type 2 DM patients was significantly lower than that in normal controls There was no significant difference between group I and group II. (3) There was a significant positive correlation between TXB2 and FBG, TG and negative correlation between 6-K-PGF18FINS and TXB2 and 6-K-PGF1a. Conclusion: ① The imbalance of TXA2 and PGI2 plays an important role in the development of type 2 diabetes mellitus and its microangiopathy. ③ The changes of plasma secreted PLA2 activity are closely related to type 2 diabetes mellitus, but may not be in the imbalance and microangiopathy of TXA2 and PGI2 in diabetic patients Play a direct role; ③ glucose and lipid metabolism disorders and hyperinsulinemia in TXA and PGI2 imbalance and DM microvascular disease plays an important role.