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自Roberts等[1-3]发现哺乳动物的大脑灰质中存有大量的γ-氨基丁酸(GABA)及其综合酶——L-谷氨酸脱羧酶(GAD)以来,对GABA在中枢神经系统中的生理功能曾进行多方面的研究。1954年Killam在研究致痉药物中发现了一些酰肼化合物可使实验动物产生癫痫样发作。在此种发作状态下,动物中枢神经系梳中的GABA水平降低,并证实了降低的原因是抑制了GABA的综合酶GAD(为B_6酶)的缘故。此种抑制作用可以给予维生素B_6而转扭转之[4]。Roberts等用同位素标记谷氨酸进行研究,亦表明在肼类中毒
Since Roberts et al. [1-3] found that a large amount of γ-aminobutyric acid (GABA) and its synthetic enzyme L-glutamic acid decarboxylase (GAD) are present in mammalian brain gray matter, The physiological functions of the system have been studied in many ways. In 1954, Killam found some acyl hydrazine compounds in the study of spasm drugs can make experimental animals epileptic seizures. In this state of seizure, the level of GABA in the central nervous system comb decreased, and the reason for the decrease was confirmed by the suppression of the GAD synthase GAD, which is a B 6 enzyme. This inhibitory effect can give vitamin B_6 and turn around [4]. Roberts et al. Used isotope-labeled glutamate to study the toxicity of hydrazines