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目的探讨血清天冬酰胺内肽酶水平检测对于脑胶质瘤诊断的临床意义。方法选取初次诊断的脑胶质瘤患者74例及正常对照患者30例,于治疗前提取血清,用ELISA法测定血清AEP浓度。结果通过统计学分析来推测血清天冬酰胺内肽酶水平在脑胶质瘤诊断中的作用。结果对照组与胶质瘤组、低级别与高级别胶质瘤组、对照组与低级别胶质瘤组、对照组与高级别胶质瘤组血清AEP水平均有显著性差异(P<0.05),ROC曲线分析AEP诊断脑胶质瘤组和正常对照组时,曲线下面积(area under curve,AUC)为0.946,临界值161.08ng/ml,敏感度85.1%,特异度93.3%。血清AEP水平的高低是脑胶质瘤发生的危险因素,OR值为80.18(95%可信区间为16.66~385.80)。结论血清AEP水平可作为诊断脑胶质瘤的肿瘤标志物,对于胶质瘤的诊断有高度敏感性和特异性,可以作为胶质瘤临床诊断的方法之一。
Objective To investigate the clinical significance of detection of serum asparagine endopeptidase in the diagnosis of glioma. Methods Totally 74 patients with initial diagnosis of glioma and 30 normal controls were enrolled. Serum was collected before treatment and serum AEP concentration was measured by ELISA. Results The role of serum asparagine endopeptidase levels in the diagnosis of gliomas was extrapolated by statistical analysis. Results Serum AEP levels were significantly different between the control group and the glioma group, the low grade and high grade glioma group, the control group and the low grade glioma group, the control group and the high grade glioma group (P <0.05 The area under curve (AUC) was 0.946, the cutoff value was 161.08ng / ml, the sensitivity was 85.1%, and the specificity was 93.3% when AEP was used to diagnose brain glioma group and normal control group by ROC curve analysis. Serum AEP level is a risk factor for glioma, OR was 80.18 (95% confidence interval 16.66 ~ 385.80). Conclusions Serum AEP level can be used as a tumor marker in the diagnosis of gliomas. It is highly sensitive and specific for the diagnosis of gliomas and can be used as one of the methods for clinical diagnosis of gliomas.