Tanshinone ⅡA improves distribution and anti-tumor efficacy of pegylated liposomal doxorubicin via n

来源 :中医杂志(英文版) | 被引量 : 0次 | 上传用户:hqxx03447
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
OBJECTIVE:To investigate whether the Tan Ⅱ A could improve the distribution and anti-tumor efficacy of Pegylated Liposomal Doxorubicin (PLD) via normalizing the structure and function of vasculature in Hepa1-6 hepatoma mice model.METHODS:Hepa1-6 hepatoma-bearing mice were treated with Tan Ⅱ A for 14 d.Distribution and anti-tumor efficacy of PLD,and the structure and function of the tumor vasculature were evaluated using various techniques.RESULTS:Tan Ⅱ A significantly reduced the micro-vessel density (MVD).After Tan Ⅱ A treatment,the tumor vascular walls were better structured,as the increased coverage of the pericytes and the promoted contact of the basement membrane and endothelial cell.Functional tests showed that tumor hypoxia was improved and the exudation amount of Evans blue in the parenchyma of the tumor decreased.In addition,mice treated with Tan Ⅱ A had greater PLD penetration distance intratumorally.Furthermore,combined therapy of Tan Ⅱ A and PLD significantly inhibited tumor growth.CONCLUSION:This study suggests that Tan Ⅱ A helps normalizing the tumor vasculature and has therapeutic potential in increasing the distribution of chemotherapy drug in the tumor.
其他文献
OBJECTIVE:To observe the clinical effect of pricking and penetrating moxibustion therapy on refractory insomnia.METHODS:Totally 60 subjects were randomly divide
OBJECTIVE:To assess the efficacy and safety in 105 patients with seasonal Influenza in Beijing,the mixture prepared with Chinese medicines follows the treatment
OBJECTIVE:To show whether Danggui Sini plus Wuzhuyu Shengjiang Tang (DSWST) has any transient effect on erythrocyte deformability in normal subjects.METHODS:A t
OBJECTIVE:To investigate the metabolic pathogenesis in subjects with subjective tinnitus (ST)having kidney deficiency patt (KDP) (ST/KDP) in terms of Traditiona
OBJECTIVE:To determine the therapeutic effect of Ziyin Jianghuo Ningxin Decoction (ZYJHNXD) plus dehydroepiandrosterone (DHEA) and menopausal hormone therapy (M
The pathogenic mechanism of diabetic kidney disease (DKD) is complex.The development of DKD cannot be fully explained by a single mechanism.Traditional Chinese
目前,全球约有1.5亿糖尿病患者,截止2003年,我国已经成为糖尿病第2大国,仅次于印度,糖尿病的患病率从1986-1994年增长了近3倍[1].被誉为美国糖尿病教育先驱的Dr.Toslm提出,糖
期刊
OBJECTIVE:To define the effects of Xanthoceras sorbifolia (EXS) on vascular inflammation and the mechanisms in endothelial cells.METHODS:Vascular protective eff