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自环孢菌素A(CsA)应用于器官移植以来,使患者的存活率提高约20%。CsA的主要缺点是可引起高血压和肾毒性。本文综述了近年来对CsA所引起的早期肾功能障碍的研究,并讨论了对付这一肾毒性的药理学途径。 CsA肾毒性的实验研究目前CsA引起肾毒性的病理生理学机制虽然尚未被充分阐明,但是可以肯定,CsA是通过收缩血管而导致肾小球灌注受损。有人在小鼠试验中用显微镜观察了CsA对囊下微循环的抑制作用,并发现作用强度与剂
Since cyclosporin A (CsA) is used in organ transplantation, the survival rate of patients increased by about 20%. The main disadvantage of CsA is its ability to cause hypertension and nephrotoxicity. This review summarizes the recent studies of CsA-induced early renal dysfunction and discusses the pharmacological approach to this nephrotoxicity. Experimental Study of CsA Nephrotoxicity Although the pathophysiology of CsA-induced nephrotoxicity has not been fully elucidated yet, it is certain that CsA is impaired glomerular perfusion by contracting blood vessels. Some people in the mouse experiment observed with a microscope CsA microcirculation inhibitory effect and found that the role of strength and dose