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为了进一步研究运动性心肌肥大发生的影响因素，本文选用１２０只雄性ＳＤ大鼠，随机分为３组：对照组和两个不同强度耐力训练组。经过１２周跑台训练后，分别对心肌组织中儿茶酚胺、肾上腺素能受体及血管紧张素Ⅱ含量进行放射酶法、放射配基结合法及放射免疫测定。结果显示，经过不同强度耐力训练后，两组心肌中儿茶酚胺分别增高２２％和５１％；α_１受体数目分别增加３６％和２０％；血管紧张素Ⅱ含量分别增加１４％和６３％。结果提示，耐力训练后增高的心肌儿茶酚胺、α_１肾上腺素能受体及血管紧张素Ⅱ可能是运动性心肌肥大发生的重要机制。
In order to further study the influencing factors of exercise-induced cardiac hypertrophy, 120 male Sprague-Dawley rats were randomly divided into three groups: control group and two training groups with different strength endurance. After 12 weeks of treadmill training, the contents of catecholamine, adrenergic receptor and angiotensin Ⅱ in myocardium were measured by radioimmunoassay, radioligand binding assay and radioimmunoassay. The results showed that the catecholamines in the two groups increased by 22% and 51%, respectively; the number of α_1 receptors increased by 36% and 20%, respectively; while the levels of angiotensin Ⅱ increased by 14% and 63% respectively. The results suggest that elevated myocardial catecholamines, α 1 adrenergic receptors and angiotensin Ⅱ after endurance training may be an important mechanism of exercise-induced cardiac hypertrophy.