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目的:探讨金属基质蛋白酶-9(MMP-9)与急性冠状动脉综合征(ACS)患者预后的相关性。方法:选取2014-04-2015-01于我院住院的371例ACS患者为研究对象,用酶联免疫吸附法(ELISA)测定患者入院时MMP-9浓度,对其随访1年,观察终点为发生心血管终点事件。结果:按随访结果将患者分为心血管事件组和对照组。心血管事件组血浆MMP-9浓度明显高于对照组(P<0.001)。多因素Logistic回归分析显示,MMP-9浓度升高、糖尿病、吸烟是ACS患者1年心血管终点事件发生的独立危险因素。结论:MMP-9与ACS患者1年心血管终点事件发生密切相关。
Objective: To investigate the correlation between MMP-9 and prognosis in patients with acute coronary syndrome (ACS). Methods: A total of 371 ACS patients hospitalized in our hospital from April 2014 to January 2015 were enrolled in this study. The concentration of MMP-9 on hospital admission was determined by enzyme-linked immunosorbent assay (ELISA). The patients were followed up for 1 year. The end point was Cardiovascular endpoints occur. Results: According to the follow-up results, patients were divided into cardiovascular events group and control group. Plasma MMP-9 levels in cardiovascular events were significantly higher than those in controls (P <0.001). Multivariate Logistic regression analysis showed that elevated MMP-9, diabetes and smoking were independent risk factors for cardiovascular events at 1 year in patients with ACS. Conclusion: There is a close relationship between MMP-9 and 1-year cardiovascular events in patients with ACS.