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[目的]探讨辛伐他汀治疗高血压伴颈动脉硬化患者的临床效果。[方法]64例高血压伴颈动脉硬化患者随机分为两组:辛伐他汀组采用辛伐他汀20mg/d+常规治疗,对照组采用常规治疗,于治疗前后6周分别测定hsCRP、TC、TG及LDL-C等指标;高频超声检测颈动脉,记录颈动脉内膜中膜厚度(IMT)、颈动脉斑块积分、斑块发生率。[结果]辛伐他汀组治疗6周后TC、TG、LDL-C、hsC-RP、颈动脉内膜中膜厚度(IMT)、颈动脉斑块积分、斑块发生率较治疗前显著下降,差异有统计学意义(P﹤0.05)。[结论]辛伐他汀治疗可改善高血压伴动脉硬化患者动脉硬化程度及炎症反应的程度,具有稳定斑块的作用。
[Objective] To investigate the clinical effect of simvastatin on patients with hypertension and carotid atherosclerosis. [Method] Sixty-four patients with hypertension and carotid atherosclerosis were randomly divided into two groups: Simvastatin group was treated with 20mg / d of simvastatin and the control group was treated routinely. HsCRP, TC, TG And LDL-C and other indicators; carotid artery was detected by high-frequency ultrasound, carotid intima-media thickness (IMT), carotid plaque score and plaque incidence were recorded. [Results] The levels of TC, TG, LDL-C, hsC-RP, carotid intima-media thickness (IMT), carotid plaque score and plaque incidence in simvastatin group were significantly lower than those before treatment The difference was statistically significant (P <0.05). [Conclusion] Simvastatin can improve the degree of atherosclerosis and inflammatory reaction in hypertensive patients with arteriosclerosis, and has the effect of stabilizing plaque.